A postdoctoral position is available immediately in the laboratory of Dr. Robert Yarchoan in the HIV and AIDS Malignancy Branch to conduct research in Kaposi sarcoma-associated herpesvirus (KSHV) and the pathogenesis of diseases caused by KSHV. The laboratory research program in the Retroviral Diseases Section is now focused on several areas, including the role of hypoxia and hypoxia-inducible factors on KSHV and KSHV-induced diseases; the interactions between KSHV and other cellular factors; a study of the pathogenesis of KSHV-associated diseases, and development of novel therapies for KSHV-associated diseases. The postdoctoral fellow will develop an individual research program within the scope of the laboratory interests. The research program can benefit from a unique translational environment that includes patients with KSHV-associated diseases. Please visit https://ccr.cancer.gov/HIV-and-AIDS-Malignancy-Branch/robert-yarchoan for more information.
Applicants should have an M.D., Ph.D., M.D./Ph.D. or similar degree is a related field and substantial laboratory research in molecular virology, especially tumor virology.
The applicant should send an email to Robert.Yarchoannih.gov containing a (1) a cover note outlining his or her experience, interest, career goals, the date when you will be available, and the names of three references; (2) a curriculum vitae, (3) and a bibliography. Letters of reference are not needed for the initial application. Please clarify if visa support will be needed and current visa status if not a US Citizen or Green Card Holder.
Selected Recent Publications:
Viollet C, Davis DA, Reczko M, Ziegelbauer JM, Pezzella F, Ragoussis J*, Yarchoan R*. Next-generation sequencing analysis reveals differential expression profiles of miRNA-mRNA target pairs in KSHV-infected cells. PLoS ONE. 2015; 10(5): e0126439. doi: 10.137/journal.pone 0126439. PMID: 25942495 *Contributed equally.
Davis DA*, Naiman NE*, Wang V, Shrestha P, Haque M, Hu D, Anagho HA, Carey RF, Davidoff KS, Yarchoan R. Identification of caspase cleavage sites in KSHV latency-associated nuclear antigen and their effects on caspase-related host defense responses. PLOS Pathogens. 2015: 11(7): e1005064. doi:10.1371/journal.ppat.1005064. PMID: 26218605 *Contributed equally.
Hu D, Wang V, Yang M, Abdullah S, Davis DA, Uldrick TS, Polizzotto MN, Veeranna RP, Pittaluga S, Tosato G, Yarchoan R. Induction of Kaposi sarcoma herpesvirus-encoded interleukin-6 by X-box binding protein-1. J. Virol. 2015, Oct 21;90(1):368-78. doi: 10.1128/JVI.01192-15. PMID: 26491160.
Polizzotto MN, Uldrick TS, Wyvill KM, Aleman K, Marshall V, Wang V, Whitby D, Pittaluga S, Jaffe E, Millo C, Tosato G, Little RF, Steinberg SM, Sereti I, Yarchoan R. Clinical features and outcomes of patients with symptomatic KSHV-associated inflammation: prospective characterization of the Kaposi sarcoma herpesvirus inflammatory cytokine syndrome (KICS). Clinical Infectious Diseases. 2016; 62(6): 730-8, PMID: 26658701.
Polizzotto MNm Uldrick TS, Wyvill KM, Aleman K, Peer CJ, Bevans M, Sereti I, Maldarelli F, Whitby D, Marshall V, Goncalves PH, Khetani V, Figg WD, Steinberg SM, Zeldis JB, Yarchoan R. Pomalidomide for symptomatic Kaposi sarcoma in people with and without HIV infection: A phase I/II study. J. Clinical Oncology, 2016; 34(34); 4125-4131. PMID: 27863194
Viollet C, Davis DA, Tekeste SS, Reczko M, Ziegelbauer JM, Pezzella F, Ragoussis J, Yarchoan R. RNA Sequencing reveals that Kaposi sarcoma-associated herpesvirus infection mimics hypoxia gene expression signature. PLoS Pathogens. In press.
The position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.