Interactions of HIV-1 Gag Protein Studied by Fluorescence and Hydrodynamics
Posted by: National Institutes of Health (NIH)
Posted date: 2017-Apr-19
Applicants are invited to apply for a postdoctoral fellowship position in the Dynamics of Macromolecular Assembly Section of the Laboratory of Cellular Imaging and Macromolecular Biophysics at the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Our research focuses on the development and application of experimental biophysical methods for the study of protein interactions and multi-protein complexes. Recently we have embarked on fluorescence detected analytical ultracentrifugation for high-affinity interactions. We seek a new member to join our group for the development and application of this technique to study the binding mechanism and cooperativity of interaction of HIV-1 Gag protein with nucleic acids and ligands in the initial stages of the assembly of viral particles.
We expect this position to be filled with a recent PhD in biophysics, biochemistry, bioengineering, or a related discipline providing solid knowledge of biological macromolecules, and be self-motivated with good communication skills. Experience in protein expression and purification is essential, as is familiarity with thermodynamics, physical biochemistry, and quantitative data analysis. Experience in one of the following areas is desirable, though not required: Analytical ultracentrifugation, isothermal titration calorimetry, fluorescence spectroscopy, and mathematical modeling.
Applicants should send a CV, a one-page description of research interests, and contact information for three references to Dr. Peter Schuck (peter.schucknih.gov). The position is located on the NIH main campus in Bethesda, Maryland, U.S.A. NIH offers excellent salary and health care packages to its trainees and has consistently been ranked among the best places to work for postdoctoral fellows. U.S. citizens and permanent residents are eligible for this position.
The NIH is dedicated to building a diverse community in its training and employment programs.