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HIV Replication and TherapeuticsPosted by: National Institutes of Health (NIH)
Posted date: 2017-Jul-13
Our overall goal is to understand how retroviruses replicate in the presence of potent host defense mechanisms and use this knowledge to develop novel strategies to control HIV-1 replication and development of AIDS. We are active in three major areas of HIV research. First, our aim is to understand the early stage of HIV-1 replication by using state-of-the-art imaging approaches to elucidate poorly understood aspects of viral replication in infected cells, including viral core uncoating and nuclear import. Second, we seek to understand the evolutionary interplay between virus and innate host defense factors. We use multiple experimental approaches to define the structure, function, and molecular interactions between the viral protein Vif and human APOBEC3 proteins, with the goal of developing novel therapeutics that target the host-virus interaction. Third, we are developing novel gene therapy approaches for the treatment of AIDS based on delivering anti-HIV genes to target cells of infection. Further details and a list of relevant publications can be found at http://home.ncifcrf.gov/hivdrp/Pathak.html.
Dr. Vinay K. Pathak
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.