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Cancer Functional GeneticsPosted by: National Institutes of Health (NIH)
Posted date: 2018-Jan-11
Our current research focuses on the development of new treatment strategies for cancers driven by fusion oncoproteins. Since only tumor cells express and depend on the products of fusion or chimeric oncogenes, a fusion transcript or protein represents an ideal molecular target. We hypothesize that proteins needed for the expression of fusion oncoproteins will reveal new therapeutic targets for tumors dependent on their oncogenic activity and potentially other cancers. Using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods our specific aims are to discover and characterize proteins required for the post-transcriptional or post-translational regulation of fusion oncoproteins. We are seeking self-motivated candidates interested in (1) the study of a protein post-translational modification and transcription factor biology, or (2) the study of RNA processing and splicing.
This position is subject to a background investigation.
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