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Post-Doctoral Fellowship for Genomic Toxicology at NCATSPosted by: National Institutes of Health (NIH)
Posted date: 2018-Jan-12
The Genomic Toxicology Laboratory participates in the Tox21 Consortium by developing methods for assessing the effects of chemicals on human health. This lab is currently developing novel methods for gene expression profiling and data analysis, as well as improving cell culture models that include 3D culture, stem cells and immortalized cells. One novel method quantitates the expression of selected genes in hundreds of thousands of cultured human cell samples. The unprecedented throughput of this method will enable screening of large chemical libraries of environmental toxicants or drug candidates. Our accompanying Point-of-Departure analytical method also enables quantitative characterization of the dose-response relationships that are the basis of toxicology and pharmacology. Because quantitative high-throughput screening of large chemical libraries (qHTS) is the core expertise of NCATS, there are pervasive needs and abundant collaborative opportunities to apply this method to identify drug candidates and to repurpose existing drugs, as well as to screen Tox21 toxicant libraries. Initially, we plan to screen toxicant libraries by assaying human genes to address cell stress pathways as well as apoptosis and cell growth arrest endpoints.
The Genomic Toxicology Lab collaborates with the Chemoinformatics group and the Systems Toxicology Lab in NCATS to support the Tox21 Consortium, which is a federal collaboration among NCATS, NIEHS, EPA, and FDA. Within the NCATS' Division of Pre-Clinical Innovation, we are assisted by core group experts dedicated to data analysis, stem cell biology, compound library management, robotics and engineering, licensing, et al. NCATS' Division of Pre-Clinical Innovation is an assay development, ultrahigh-throughput screening and chemistry center which discovers chemical probes of protein and cell functions. The scope of this translationally-focused resource is unparalleled outside of large, proprietary pharmaceutical facilities. It develops new paradigms to enable chemical genomics and develops chemical starting points for new drugs for rare genetic and orphan diseases. The work enables, but is not constrained by, the demands of future commercialization. Located 10 minutes north of the NIH Campus in Rockville, MD, the Center has a staff of over 60 biologists, chemists, engineers, and informatics scientists, who work with investigators throughout NIH and the world to translate the genome into biological function and therapeutics.
Applicants must be US citizens, legal residents, or possess a valid work permit, in order to be considered for the position.
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