Our laboratory studies the regulation of in innate immune cells in the context of cancer with a current emphasis on regulation of metabolism. We utilize in vitro biochemical approaches, metabolomics, metabolic flux analysis, heavy isotope tracing, and animal models to dissect metabolic pathways. The laboratory currently has projects running investigating metabolic control of NK cells, monocytes/macrophages and neutrophils. In addition, as part of the NCI Cancer and Inflammation Program (CIP), we translate these projects in to in vivo models of inflammation and carcinogenesis.
This position is available spring/summer 2018 and candidates will be considered until the position is filled. The NCI-Frederick campus is located about 40 miles northwest of Washington DC in the foothills of the Blue Ridge Mountains. The campus houses scores of NCI principal investigators, state-of-the-art animal facilities, and the NCI mass spec, genetics, transgene, knockout, and germ-free cores.
Applicants must have a Ph.D. and/or MD and less than five years of postdoctoral experience. Demonstrable knowledge and experience in the biochemistry of metabolism is an absolute necessity. Experience with the methods, technologies (LC-MS, NMR etc.), and datasets associated with metabolic studies is highly recommended. The CIP is a multidisciplinary program of investigators with expertise in metabolism, cancer models, signaling, molecular biology, genetics, the microbiome, and inflammation, providing trainees with a broad range of collaborative training opportunities.
To be considered, candidates must submit, 1) a CV, 2) statement of research experience and career goals, 3) contact information for three references, and 4) a brief (1-2 page) description of proposed lines of inquiry that build on current themes in immunometabolism. Please submit to mcvicardmail.nih.gov
Daniel W. McVicar, Ph.D.
Deputy Director, Center for Cancer Research
Deputy Director for Basic Science, Cancer and Inflammation Program, National Cancer Institute-Frederick
Frederick, MD 21702
(301) 846-5163 (office)
(301) 846-1673 (Fax)
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