Open position for a highly-motivated postdoctoral candidate committed to research in human genomics. The overarching goal of the lab is to use molecular and cellular biology to test hypotheses based on large-scale data analysis, to discover disease mechanisms in cancer and other diseases. Research entails next generation sequencing of clinical samples at the NIH Intramural Sequencing Center, in silico mining of large publically available genomic datasets, including DNA methylation, RNA-sequence data and cancer mutations. Large scale data analyses are utilized for hypothesis generation followed by in silico and functional testing of regulatory processes controlling gene expression, including DNA methylation, RNA splicing and diagnostic cancer assays, known as liquid biopsies. The successful applicant will use experimental approaches to manipulate gene functions and test results on RNA splicing or DNA methylation patterns to identify mechanisms of disease causality. The overarching goal of utilizing molecular, biochemical, and cellular approaches is to functionally validate predictions in selected genes-of-interest. Access to extensive core facilities including cores in bioinformatics, microarrays, copy number analysis, flow cytometry, cytogenetics, and a transgenic mouse core, offers the trainee wide latitude in the design and pursuit of their research questions. Career development opportunities are extensive and aimed at developing candidates into well rounded, independent investigators ready for future advancement. Programs are made available through the NHGRI Intramural Training Office and the NIH Office of Intramural Training and Education. The NIH is dedicated to building a diverse community in its training and employment programs.
Successful candidates should have or be very close to obtaining a PhD and have less than two years of Postdoctoral experience. Applicants must have a strong background in molecular/cellular biology and biochemistry, cell culture, and DNA cloning. Experience in are biostatistics and bioinformatics are highly desirable. A demonstrated record of scientific accomplishment, including first authorships in peer reviewed journals, strong work ethic, and strong intellectual commitments to disease research and to one's individual research project, are essential. The successful candidate should possess excellent interpersonal and organizational skills, enjoy presenting at scientific venues, and demonstrate stellar communication skills with fluency in both spoken and written English. Applicant must provide 3 letters of recommendation.
Suitably qualified candidates should submit their curriculum vitae, cover letter, and the names and contact information for three referees to Dr. Laura Elnitski at mail.nih.gov ">elnitskimail.nih.gov
Salary will be commensurate with research experience in the NIH system. Applications accepted until position is filled.
The NIH is dedicated to building a diverse community in its training and employment programs.