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Structural and Functional Studies of GlycosyltransferasesPosted by: National Institutes of Health (NIH)
Posted date: 2018-Jul-10
We are seeking a postdoctoral researcher to study the mechanisms of protein glycosylation. Our overall goal is to understand how glycosyltransferases modify their substrates in order to better understand their biological functions. A long-standing project focuses on a family of enzymes called UDP-GalNAc:polypeptide N-Acetylgalactosaminyltransferases (GalNAc-Ts), which initiate the first step in mucin-type O-glycosylation, a modification that is critical for protein stability, signaling, and immunity. Disruption of this pathway is linked to many different cancers and aberration of normal development. A new project will elucidate the structures of bacterial glycosyltransferases involved in capsular polysaccharide (CPS) synthesis. CPSs have been shown to be important for pathogenesis and are targets for antibiotics. Our goal will be to understand the synthesis machinery in order to identify potential drug targets that can inhibit CPS synthesis.
We are seeking highly motivated candidates with a Ph.D. in the biomedical sciences, strong verbal and writing skills, and experience in structural biology and biochemistry. Knowledge and experience with mass spectrometry is a plus. Salary is commensurate with research experience and accomplishments.To Apply:
Please submit your CV, bibliography, a brief statement of research interests, and the names of 3 references to both:
Lawrence Tabak, D.D.S., Ph.D.
NIH/NIDCR is dedicated to building an inclusive and diverse community in its training and employment programs. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH/NIDCR employment. DHHS and NIH are equal opportunity employers.