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Mechanisms and Regulation of Human Nonsense-Mediated mRNA DecayPosted by: National Institutes of Health (NIH)
Posted date: 2018-Aug-08
A postdoctoral position studying the molecular mechanisms of RNA quality control is immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. The laboratory is an RNA biochemistry and molecular biology research group established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The research of the group and its members is supported by the collaborative and interdisciplinary NIH intramural program and state-of-the-art proteomics, high-throughput sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse transgenic, and other core facilities.
We are seeking a postdoctoral fellow to extend our recent efforts to identify and investigate new members of the human NMD pathway. In collaboration with colleagues at NIH, we have recently used whole-genome siRNA screening to discover multiple novel nonsense-mediated decay factors, including ICE1, a protein that promotes the link between the exon junction complex and the NMD machinery (see Baird et al., Elife, 2018). We are currently working to understand the mechanism and regulation of ICE1 function in NMD, in addition to using the siRNA screen to identify additional new NMD proteins.Qualifications:
Interested candidates must have received a Ph.D. or M.D. within the past five years in molecular biology, cell biology, biochemistry, genetics or a related discipline and be highly motivated to participate in and design innovative research programs. Candidates with expertise in bioinformatics are particularly encouraged to apply. The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.To Apply:
Please email a cover letter indicating preferred start date and research area, CV, summary of research accomplishments, and names and contact information for at least three references to:
Dr. J. Robert Hogg
The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer