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Mitochondrial Function in Heart and AutoimmunityPosted by: National Institutes of Health (NIH)
Posted date: 2018-Sep-21
Mitochondrial dysfunction is not only associated with metabolic defects but with autoimmunity. Both obesity and aging are associated with mitochondrial dysfunction. We have recently discovered a novel link between mitochondrial function and type-I interferon signaling and would like to explore one of the following two topics: 1. The role of DNA-PK in cardiac mitochondria and heart contractility; 2. Pathways that link mitochondrial function and inflammation.
These projects build on our recent finding that aging-related suppression of AMPK and mitochondrial activity is mediated by DNA-PK expressed in muscle, which increases in activity with aging and promotes obesity and type 2 diabetes (Park et al. Cell Metabolism 2017).
This position gives the postdoctoral candidate a wide latitude on the pathway the candidate chooses to study. The specific nature of the project will be determined in part by the candidate’s previous experience and future research and career interests.
For more details, go to the Cardiovascular Branch, Laboratory of Obesity and Aging Research, Jay H. Chung lab website: https://irp.nih.gov/pi/jay-chungQualifications:
Candidates should have a Ph.D. and/or M.D. degree (or anticipate receiving their degree in the near future) and experience in molecular biology and cell biology and relevant publications in peer-reviewed journals. Candidates with less than three years of post-doctoral experience are preferred.To Apply:
Interested individuals should email their CV, a cover letter summarizing current and future research interests, and contact information for three references to:
Jay H. Chung MD, PhD
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