Career|edu

Find Jobs

Category
Location
Org Name
Description (only in English)

Employers

Post & Manage Jobs

Job Seekers

 Job Seeker ID 
 Password 
 

Join now! | Forgot your password?

Jobs by Category

Category (70)
Exec/Dept Head (0)
Staff (7)
PhD Student (34)
Postdoctoral (27)
Faculty (2)
Central America (70)
AFRICA (0)
Central America (0)
ASIA (0)
AU & NZ (1)
CANADA (0)
EUROPE (69)
LAT AMERICA (0)
MIDDLE EAST (0)
USA (0)
FactCards - All you need to know to do research in the Netherlands
AcademicTransfer offers all academic positions in The Netherlands!
CareerEdu Information
University of Groningen logo
Eindhoven University of Technology logo
Jobs in Germany Help? Advertising About Us
Job Board for the international Academic and Research Community

We have changed our domain

We have changed servers and operate Career|edu under a different domain. Our services will remain unchanged and we will continue to post the best career openings for the academic world at our new domain.
Please bookmark careeredu.eu.

Go back to the Job List

** Please mention Career|edu when replying to this advertisement **

Email to friendEmail this Job

Epigenetic Mechanisms of Human Disease

Posted by: Postdoc positions by NIH

Posted date: 2018-Nov-30

Location: USA

Position Description:

Postdoctoral position is available at the Andrew Feinberg lab in the JHU Center for Epigenetics for study of the epigenetics of cancer, metabolism, and behavior, focused on disease mechanisms, model organisms, and the role of epigenetics in gene-environment interaction. All of the studies are interdisciplinary, involving collaborating faculty in experimental design and mentorship at the Johns Hopkins University School of Medicine, preparing fellows for team-based jobs grounded in outstanding scholarship. We are addressing the following scientific questions:

  • What are the epigenetic drivers of cancer progression? We are determining how mutations in epigenetic modifier genes alter the epigenetic landscape in normal development and cancer, and increase epigenetic plasticity and tumor cell survival. See Feinberg et al, Nature Rev Genet 2016, 17:284.
  • Can epigenetic alterations in cancer be reversed using novel approaches targeted to large blocks of heterochromatin and/or metabolism? See: McDonald et al, Nature Genet 2017, 49:367.
  • What are the epigenetic drivers of neuropsychiatric disease and how are they related to brain-region specific developmental epigenetic marks? See: Rizzardi et al, Nature Neurosci, in press.
  • What is the relationship between common DNA sequence variants and tissue-specific epigenetic marks in normal development and disease? See: eGTEx Project, Nature Genet 2017, 49:1664.
  • How do genome and environment interact to cause disease, and how is this mediated by the epigenome? We are addressing the mechanisms through which environment influences gene function, or “GxE”, focusing on important and contemporary exposures highly relevant to human health: diet, environmental toxicants and their relationship to metabolic disorders and cancer. See: Barrington et al, Genetics 2018, 208:399.
  • What is the mathematical foundation of epigenetic information? We are pursuing our novel idea that genetic variants that control phenotypic variance confer a selective advantage in evolution in an environment that changes, and that the same idea may explain phenotypic plasticity in cancer evolution, with the “hallmarks” of cancer being selected for at the expense of the host. We are developing new information theoretic tools to relate DNA methylation, chromatin structure, and gene sequence to stochastic modeling. See: Jenkinson et al, Nature Genet 2017, 49:719.

See our website for details: http://feinberglab.jhu.edu.

Qualifications:

Interested candidates must have received or expect to have received the PhD or MD/PhD in 2018 or 2019, have a strong graduate school record in genetics and/or biostatistics, and have published or have accepted one or more high-quality peer reviewed publications.

To Apply:

To apply, please upload to this website a cover letter, C.V. including bibliography, unofficial graduate school transcript, and contact information for three references, but do not have them send letters at this time. Any questions about the position or application process can be directed to Michael Graziano at graziano(at)jhmi.edu, but only applications submitted through this website will be considered.

Job Title (only in English) Epigenetic Mechanisms of Human Disease
POST DETAILS
Org Name Postdoc positions by NIH
Country USA
Application Deadline
CATEGORY
Location
Category
Job opening URL https://www.training.nih.gov/postdoc_jobs/view/_27/6027/Epigenetic_Mechanis...





Terms & conditions | Privacy |  Copyright © 2008-2011 Coöperatieve Vereniging AcademicTransfer U.A.