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Cell/Gene Therapy & Tumor ImmunologyPosted by: Postdoc positions by NIH
Posted date: 2019-Jan-03
We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a post-doctoral research fellow. We recently identified mechanisms of response and resistance to chimeric antigen receptor (CAR) T cell therapy in leukemias 1. Our laboratory focuses on the functional fate mapping of CAR T cells using high-end single cell transcriptomics and proteomics approaches, combined with functional in vitro and in vivo mechanistic studies to further understand the long-term persistent memory CAR T cells and translate such findings into novel gene therapies for cancer.
We have a post-doctoral position open to support these efforts. This position will utilize next-generation single cell technologies to characterize and monitor chimeric antigen receptor (CAR) T cells from leukemia patients treated at our center with autologous CD19 CAR-redirected T cells. In addition, this position will study the biology of the CAR integration on the local, regional, and global gene activity in the modified T cells via gene editing technologies and deep mechanistic studies.Qualifications:
Preferred: Experience in tumor immunology and immunotherapy, mass cytometry, flow cytometric purification of cell populations using the BD Aria, substantial expertise with human/murine T cell functional assays (especially high definition polychromatic flow cytometry), gene editing via CRISPR/Cas9, and tumor mouse models, scientific knowledge and research experience in human immunology with a track record of publication in peer-reviewed journals.
Basic: Ph.D. and/or M.D. in immunology or genetics. Must have research experience in the cellular and molecular aspects of tumor immunology. Able to work well in a highly dynamic, collaborative work environment.To Apply:
Please forward a cover letter describing your career plans, updated CV with research statement and the names/contact information for 3 professional references to:
J. Joseph Melenhorst, PhD