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Regenerative Therapies for Inherited Blood DisordersPosted by: National Institutes of Health (NIH)
Posted date: 2019-Jan-21
The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) is seeking to recruit two outstanding post-doctoral fellows to participate in the research program of the Section for Regenerative Therapies for Inherited Blood Disorders of the Cellular and Molecular Therapeutics Branch (CMTB), led by Dr. Andre Larochelle (https://www.nhlbi.nih.gov/science/regenerative-therapies-inherited-blood-disorders).
This laboratory is investigating novel strategies and stem cell concepts to advance the translational field of regenerative medicine, with a focus on inherited disorders affecting blood-forming hematopoietic stem cells (HSCs), including: 1) Gene therapy: Genetic correction of adult HSCs using CRISPR/Cas and viral vector technologies, and ex vivo expansion of genetically corrected HSCs; 2) Cell Therapy: Derivation of engraftable HSCs from genetically corrected induced pluripotent stem cells (iPSCs); 3) Drug Therapy: Expansion of adult HSCs in vivo using the small molecule eltrombopag, and high-throughput screens for alternative small molecules. There are strong interactions with a wide range of dynamic, independent research groups, and the position offers exceptional opportunities for interdisciplinary collaboration within and outside of the NIH.Qualifications:
The successful candidates should have a strong track record of achievement, expertise, creativity, passion and experience in laboratory research. Applicants must have:
Applications should include a 1-2 page letter of interest, curriculum vitae with complete bibliography, and contact information for three references (letters not required at first inquiry), to be sent by e-mail to:
Andre Larochelle, M.D., Ph.D.
The review of applications will begin on January 22nd, 2019.
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