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Regulation of Nuclear Size in Budding YeastPosted by: National Institutes of Health (NIH)
Posted date: 2019-Jan-29
A postdoctoral position is available starting spring/summer 2019 to study the regulation of nuclear size in budding yeast. The position is in the lab of Dr. Orna Cohen-Fix at the NIH, in Bethesda MD. Studies in the Cohen-Fix lab focus on understanding the relationship between nuclear structure and nuclear function. Alterations in nuclear morphology are observed under a variety of conditions and diseases, such as aging and cancer, but the impact of altered nuclear shape or size on nuclear and cell function is poorly understood. It has long been known that cells exhibit a constant nuclear/cell volume ratio, but the mechanism responsible for this constant ratio is not known. We are in the process of identifying a number of yeast mutants that exhibit an altered nuclear:cell volume ratio. The aim of the post-doctoral project will be to understand how the identified genes affect nuclear size and the consequences of this alteration. This project will entail a wide array of experimental approaches, including genetics, molecular biology and cellular biology/microscopy. The roles of these genes in nuclear morphology in other model organisms could also be tested.
For recent publications from the lab please see: https://www.ncbi.nlm.nih.gov/sites/myncbi/orna.cohen-fix.1/bibliography/46582560/public/?sort=date&direction=descendingQualification:
A strong background in molecular biology, cell biology and/or genetics is required. Experience in working with budding yeast is an advantage. Applicants must have a Ph.D. or an M.D degree and should have less than five years of postdoctoral experience.To Apply:
To submit an application, please contact Dr. Orna Cohen-Fix at ornacniddk.nih.gov. When applying, please include a CV, a statement of research interest (and, in particular, why you would like to join the lab) and the names of three people who can provide letters of reference.
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