Genetic, Cellular and Biochemical Studies of T lymphocyte Signaling and Function

The work in the Cell Signaling in Immunity Section focuses on signaling pathways in T lymphocytes with an emphasis on understanding molecules that are affected by primary immunodeficiencies and how they regulate normal immune cell development and function. We take a multidisciplinary approach using mouse genetics, cell biology, biochemistry and genomics, coupled with studies of infectious disease and immunization, to examine the functions of signaling molecules in T and B lymphocytes and how they affect immune responses. Additional approaches include use of CRISPR-mediated gene disruption screens to uncover new pathways affecting functions of T and B lymphocytes including studies of T follicular helper cells, T cell signaling and adhesion and CD8 T cell responses to viral infection. We complement this work with studies of T cells from patients with genetic primary immunodeficiencies, focusing on understanding the mechanisms leading to cellular dysfunction in these diseases. Our overall goals are to provide insight into the normal regulation of the immune system and how T lymphocytes help orchestrate responses to infection and immunization.

For some recent references, see Preite et al. Nature Immunol. 2018; Huang et al. Curr Prot Immunol. 2018; Wu et al. Science Immunol. 2016, Cell Reports 2015; Gomez-Rodriguez et al. Nature Comm. 2016, JEM 2014; Tsang et al. Cell 2014; Lucas et al. Nature Immunol. 2014, and Zhao et al. and Kagayama et al. Immunity 2012).

We are looking for a bright, motivated and interactive scientist with a recent PhD and/or MD and experience in the areas of cellular and molecular biology, immunology, genetics and genomics, biochemistry, bioinformatics, infectious diseases and/or imaging.  

Interested applicants should send a CV and names of 3 references, as well as a brief summary of their previous research and future goals to: Pam Schwartzberg: pamsnih.gov

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