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Structural and Functional Studies of GlycosyltransferasesPosted by: National Institutes of Health (NIH)
Posted date: 2019-Apr-16
The Samara lab will join the National Institute of Dental and Craniofacial Research at The National Institutes of Health in the coming months, and we are seeking a postdoctoral researcher to join our new group. Our lab will use structural and biochemical methods to study the mechanisms of glycosylation.
One project in the lab is to understand how a family of enzymes called UDP-GalNAc:polypeptide N-Acetylgalactosaminyltransferases (GalNAc-Ts) modify substrates. GalNAc-Ts initiate the first step in mucin-type O-glycosylation, a modification that is critical for host-microbiome interactions, protein stability, signaling, and innate immunity. Disruption of this pathway is linked to cancer progression and aberration of normal development. Recent work in collaboration with the Ten Hagen lab (Ji et al., Nat Commun, 2018;9:3508) has defined the structural mechanisms that underlie the substrate specificities of these enzymes.
A second project in the lab will center on characterizing the bacterial glycosyltransferases that synthesize polysaccharide based virulence factors such as capsular polysaccharide (CPS), lipopolysaccharide (LPS), and extracellular polymeric substance (EPS) in biofilm, which are important for bacterial pathogenesis. Understanding how bacterial glycosyltransferases synthesize glycan structures at atomic resolution will provide insight into targeting and inhibiting these enzymes in the treatment of bacterial infections.Qualifications:
We are seeking a highly motivated candidate with a Ph.D. in the biomedical sciences, strong verbal and writing skills, and experience in structural biology and biochemistry. Knowledge and experience in structural biology of membrane proteins is a plus. Salary is commensurate with research experience and accomplishments.To Apply:
Please submit your CV, bibliography, a brief statement of research interests, and the names of 3 references to:
Nadine Samara, Ph.D.
NIH/NIDCR is dedicated to building an inclusive and diverse community in its training and employment programs. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH/NIDCR employment. DHHS and NIH are equal opportunity employers.