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Protein Signaling Networks in Innate ImmunityPosted by: National Institutes of Health (NIH)
Posted date: 2019-May-24
We are recruiting a highly motivated Postdoctoral Research Fellow to study the protein signaling mechanisms in the cellular networks regulating inflammation and innate immunity.
Our research focuses on understanding the changes that occur in the cell proteome in response to exogenous factors such as pathogen-derived molecules, cytokines, and chemokines, which alter the differentiation state of cells in the immune system or whose production characterizes specific disease states. We are especially interested in large-scale absolute quantitative measurements of immune cell signaling cascade components and in the characterization of post-translational modification (PTM) dynamics on a global scale, protein-protein interactions and their implications in the inflammatory process initiated by the Toll-like receptors and the inflammasome, and the cellular processes that follow the encounter with pathogens, commensals, and tissue damage. We aim to develop mechanistic computational models that can be used to predict the behavior of this complex biological system and help explain the basis for physiological and pathological responses to infection or vaccination or to design new therapies or vaccines.
The position offers a vibrant and highly interactive setting in the NIH Intramural Research Program, a new state-of-the-art research lab, access to outstanding resources and technology platforms, strong computational support, and a friendly, collaborative and interdisciplinary group of colleagues in both the clinical and basic sciences.
The successful applicant will join the laboratory of Dr. Aleksandra Nita-Lazar, the Functional Cellular Networks Section within the Laboratory of Immune System Biology of the National Institute of Allergy and Infectious Diseases at the main NIH campus in Bethesda, Maryland. Information about Dr. Nita-Lazar and her laboratory can be found at https://www.niaid.nih.gov/research/aleksandra-nita-lazar-phd.Qualifications:
Candidates should have a recent (less than 5 years) PhD (preferably in biochemistry or molecular immunology) and/or MD degree. Prior experience in proteomics is highly desirable; formal training in systems biology is encouraged. Knowledge of cell biology, protein chemistry, flow cytometry and big data analysis methods as well as ability to work collaboratively would be an asset.To Apply:
Applicants should contact Dr. Nita-Lazar directly at nitalazarauniaid.nih.gov submitting a cover letter, curriculum vitae, and contact information for three references. To ensure full consideration, the application materials must be received by August 1, 2019, but applications will be accepted until the position is filled.
The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.