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Genetic, Cellular and Biochemical Studies of T lymphocyte Signaling and FunctionPosted by: National Institutes of Health (NIH)
Posted date: 2019-May-24
Postdoctoral position available to study signaling pathways in T (and B) lymphocytes with an emphasis on understanding molecules that are affected by primary immunodeficiencies and how they regulate normal immune cell development and function. We take a multidisciplinary approach using mouse genetics, cell biology, biochemistry, imaging and genomics, coupled with studies of infectious disease and immunization, to examine the functions of signaling molecules in T and B lymphocytes and how they affect immune responses. Additional approaches include use of CRISPR-mediated gene disruption screens to uncover new pathways affecting function of murine T and B lymphocytes including studies of T follicular helper cells, T cell signaling and adhesion, and CD8 T cell responses to viral infection. We complement this work with studies of T cells from patients, focusing on responses to immunization and understanding the mechanisms leading to cellular dysfunction in disease. Our overall goals are to provide insight into how T lymphocytes help orchestrate responses to infection and immunization.Recent references:
Preite et al. Nature Immunol. 2018; Chen et al. Nature Immunol. 2019 in press; Huang et al. Curr Prot Immunol. 2018; Wu et al. Science Immunol. 2016, Cell Reports 2015; Gomez-Rodriguez et al. Nature Comm. 2016, JEM2014; Tsang et al. Cell 2014; Lucas et al. Nature Immunol. 2014; Zhao et al. Immunity 2012).Qualifications:
We are looking for a bright, motivated and interactive scientist with a recent PhD and/or MD and experience in the areas of cellular and molecular biology, immunology, mouse genetics, genomics, biochemistry, bioinformatics, infectious diseases and/or imaging. Candidates must have less than 4 years postdoctoral experience.To Apply:
Please send a cover letter describing your research experience, current interests and future goals, CV including bibliography, and contact information for three references to Pam Schwartzberg at pamsnih.gov.
The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.