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Inflammation and AutoimmunityPosted by: National Institutes of Health (NIH)
Posted date: 2019-Jun-14
A postdoctoral position is available in the Inflammation and Autoimmunity Group of Dr. Jennifer Martinez in the Immunity, Inflammation and Disease Laboratory at the National Institutes of Health (NIH).
The Inflammation and Autoimmunity Group focuses on the mechanisms of non-canonical autophagy and its role in limiting the inflammatory response. Defects in the autophagic machinery have been associated with aberrant host defense, inflammatory disease, and age-related disorders, though recent evidence reveals that the two conserved pathways of autophagy and phagocytosis can intersect, representing a novel mechanism wherein the crosstalk between engulfment and processing ultimately shapes the immune response. This process, termed LC3-associated phagocytosis (LAP), occurs when an extracellular pathogen is sensed and phagocytosed, triggering the recruitment of some, but not all, components of the autophagy machinery to the pathogen-containing vesicle. It is the activity of these autophagic players that facilitates the rapid destruction of the pathogen via the lysosomal pathway. LAP can shape the pursuant immune response, alter the metabolic state of the cells, and play a critical role in the pathogenesis of autoimmune disorders.Qualifications:
The Martinez lab is seeking a highly motivated postdoctoral researcher with a strong background in immunology and molecular biology to explore the role of LAP in a variety of scenarios, including infectious disease, shaping the B cell response/antibody repertoire, and the role of LAP in non-professional phagocytes. Projects will require work in molecular and signaling pathways, as well as models of immunopathology. Excellent communication skills and fluency in both spoken and written English are essential. Salary will be commensurate with research experience.To Apply:
Interested candidates should submit their curriculum vitae, a detailed letter of interest, and the names and contact information for three referees to Dr. Jennifer Martinez at jennifer.martinez3nih.gov.
The NIH is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.