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GlycobiologyPosted by: National Institutes of Health (NIH)
Posted date: 2019-Jul-03
A postdoctoral fellowship is available for an outstanding scientist to to characterize the O-glycome, i.e. all known sites mucin-type O-glycosylation in an organism. The O-glycome is defined by the substrate specificities of the multi-gene family of enzymes that catalyze the formation the core Ser/Thr-GalNAc linkage upon which O-glycans are built. Prior work from our group (https://irp.nih.gov/pi/lawrence-tabak - for example, Fritz et al., Proc. Natl Acad. Sci. USA, 2004;101:15307; and, Raman et al., J. Biol. Chem. 2008;283:22942) together with more recent collaborative studies with the Drs. Kelly Ten Hagen and Nadine Samara (e.g. Ji et al., Nat Commun, 2018;9:3508) have defined the structural mechanisms that underlie the substrate specificities of these enzymes.
While approaches to delineating sites of O-glycosylation have been developed for simple, genetically engineered cell lines, to date there is no universal approach to study the entire O-glycome of a tissue extract or biological fluid. Therefore, our next goal is to develop appropriate chemical and/or enzymatic conditions that cleave O-glycans while leaving the modified core protein substrate assayable by mass spectrometry. In collaboration with the Ten Hagen lab (https://irp.nih.gov/pi/kelly-ten-hagen), this platform will be used to deduce substrates contributing to biologically relevant phenotypes when specific GalNAc-Ts are genetically ablated in mice (e.g. Tian et al., PLoS One, 2015;10:e0115861) and flies (e.g. Zhang et al., Proc Natl Acad Sci U S A. 2014;111;7296).
We are seeking a highly motivated candidate with a Ph.D. in the biomedical sciences, strong verbal and writing skills, and experience in protein chemistry, and/or glycobiology. Salary is commensurate with research experience and accomplishments.To Apply:
Please submit your CV, bibliography, a brief statement of research interests, and the names of 3 references to: Lawrence A. Tabak, DDS, PhD – Lawrence.Tabaknih.gov
NIH/NIDCR is dedicated to building an inclusive and diverse community in its training and employment programs. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH/NIDCR employment. DHHS and NIH are equal opportunity employers.