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Doctoral Grant, Cellular and molecular neuropathology in animal models for multiple sclerosis - 2019BAPFGGWEF232Posted by: University of Antwerp
Posted date: 2019-Jul-10
The University of Antwerp is seeking to fill the following full-time vacancy (m/f) within the Experimental Cell Transplantation Group of the Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), Faculty of Medicine and Health Sciences:
Doctoral Grant - PMSMatTrain ITN Early Stage Researcher “cellular and molecular neuropathology in animal models for multiple sclerosis”
Ref. No. PMSMatTrain – ESR-10
The PMSMatTrain project is funded by the European Union Horizon 2020 Programme under the Marie Skłodowska-Curie Initial Training Network for Early Stage Researchers (ESR) (H2020-MSCA-ITN-2018, Grant Agreement No. 813263). The ESR-10 position will be available from on January 2020 on a temporary basis for a maximum period of 3 years (renewable 1 year full-time employment contract upon positive evaluation).
The PMSMatTrain project focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). This multidisciplinary network will educate and train 15 Early Stage Researchers in device design, biomaterials, materials science, stem cell biology, in vitro, ex vivo and in vivo models of multiple sclerosis, molecular biology, in silico modelling of CSF flow, material functionalisation strategies and device validation.
Programme fellows will experience both public and private sector research & development training and will be best placed to secure employment as high calibre, innovative and well-trained graduates.
Core activities of the Experimental Cell Transplantation Group
The core R&D activity of the Experimental Cell Transplantation Group is to investigate whether and how immunomodulating cell or gene therapeutic approaches, as well therapeutic compound delivery, can influence both microglia and macrophage immune responses during neuro-inflammatory events in the central nervous system. These topics are experimentally investigated in vivo using animal models for multiple sclerosis, spinal cord injury and stroke, as well as in vitro using iPSC-derived microglia and macrophage cultures. Experimental techniques applied include: embryonic/adult stem cell culture and genetic engineering, stem cell transplantation in rodent models of neuro-inflammation, fluorescent animal models, flow cytometric monitoring of immune responses, in vivo bio-imaging and quantitative histological analyses.
You will develop and validate cellular and molecular tools that enable to follow up inflammation, demyelination and remyelination in animal models for MS. These tools will be applied to test the therapeutic efficacy of a novel device housing a multi-modal hydrogel, to modulate inflammation, re-myelination and neuroprotection. The project a wide range of techniques including the use of reporter-gene animal models, flow cytometry, histology, molecular biology and advanced stem cell culture models. At the University of Antwerp you will highly interact with ESR-9 who will be responsible for developing and applying neuro-MRI tools to follow up inflammation, demyelination and remyelination in animal models for MS, as well as upon therapeutic intervention. Internationally, you will directly interact with two or more ESRs from different participating organisations during one or more secondments abroad.
Duties and Responsibilities
The remuneration will be in line with the European Commission rules for Marie Skłodowska-Curie grant holders (Early-Stage Researchers, Initial Training Network).
Start date: Position is available from on January 2020.
Continuing Professional Development/Training
Informal enquiries concerning the post may be made to Prof. Peter Ponsaerts: peter.ponsaertsuantwerpen.be.
Applications (in English) should include a CV (Please use the Europass template: https://europass.cedefop.europa.eu/editors/en/cv/compose), certificates of examination grades, a motivation letter (max. one page) describing your research career goals, skills and experience, as well as two letters of recommendation. Please send applications by e-mail (in PDF only) to Peter Ponsaerts (Peter.Ponsaertsuantwerpen.be). Please quote the project name and reference number "Application, PMSMatTrain-ESRs-10” in the subject line of e-mail application.
Closing date for receipt of applications is September 15th, 2019.
All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.
This project has been funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement.
The University of Antwerp is a family friendly organization, with a focus on equal opportunities and diversity. Our HR-policy for researchers was awarded by the European Commission with the quality label HR Excellence in research.
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