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Calcium Signaling and Regulation of Cell FunctionPosted by: National Institutes of Health (NIH)
Posted date: 2019-Jul-31
Postdoctoral position is currently available in the Secretory Physiology Section, NIDCR, NIH, to study the molecular mechanisms underlying calcium signaling. Our studies strive to elucidate the relevance of ER-PM junctions in assembly and regulation of STIM/Orai channel complex as well as in the co-ordination of channel function with cellular Ca2+ signaling mechanisms. The current project aims to identify and characterize the molecular components in the ER and plasma membrane that are involved in STIM1/Orai regulation by utilizing calcium and advanced molecular imaging approaches together with molecular/genetic manipulation of cells. Studies will also address the molecular basis by which Ca2+ signals generated by STIM1/Orai1 are utilized for regulation of specific cell function. Our research also includes studies on the role of oxidative and immune stress on cellular Ca2+ signaling mechanisms and their contribution to disease and dysfunction.
The lab is situated in the main campus of NIH in Bethesda, MD and lab offers a highly-collaborative, multi-cultural, training environment for young scientists with cutting-edge resources and expertise. The salary and benefits are as per NIH regulations commensurate with experience.Qualifications:
Applicants should have a Ph.D. with less than 3 years of postdoctoral experience, good oral and written communication skills and a strong background in physiology and biochemistry. Expertise in cellular imaging, molecular biology, and various biochemistry techniques are required. Additional experience in calcium signaling, working with animal models, and electrophysiology are highly desirable.To Apply:
If interested, please send an email with details of research experience and technical expertise, together with a complete CV and the names and contact information of three references to Dr. Indu Ambudkar (indu.ambudkarnih.gov).
The NIH is dedicated to building a diverse community in its training and employment programs. The NIH is an equal opportunity employer.