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Investigating the architecture and function of centrosomal self-assemblies using X-ray crystallography, NMR, cryo-EM, or single molecule trackingPosted by: National Institutes of Health (NIH)
Posted date: 2019-Aug-24
The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies. Investigating how these molecules interact with one another to form a higher-order structural entity that offers a new biological function is a key step to unlocking the mystery of life. We are mainly interested in understanding the molecular basis of how diverse protein complexes are generated and how these complexes cooperate to generate a micron-scale self-assembly with distinct cellular functions. Recently, we found that mammalian polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffolds, which generate a higher-order self-assembled architecture in a concentration-dependent manner. A failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly. Thus, we aim to investigate the molecular mechanisms of how these proteins self-assemble into a higher-order architecture to promote cellular processes centrally required for cell cycle progression and proliferation.
Aside from this project, we are also interested in carrying out structure-based drug design aiming at developing small molecule anticancer therapeutics against the polo-box domain of Plk1.Qualifications:
Fellows who have an expertise in structural biology (X-ray or NMR), single molecule tracking, or cryo-EM are encouraged to apply. Applicants should have a Ph.D. (or expected) or M.D. equivalent at the time of joining the lab. For more information, please visit: https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee. This position is subject to a background investigation.To Apply:
Please send CV and three names of references to Dr. Kyung Lee (kyungleemail.nih.gov). Starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance.
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