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Cancer Stem Cell BiologyPosted by: National Institutes of Health (NIH)
Posted date: 2019-Sep-26
A fully-funded postdoctoral position is available immediately in the Cancer Biology of TGF-β (CBOT) Section, Lab of Cancer Biology and Genetics (LCBG), Center for Cancer Research to perform basic research into the properties and regulation of breast cancer stem cells
The LCBG is a large multidisciplinary and highly interactive laboratory in the National Cancer Institute with expertise in many different aspects of cancer biology and genetics (https://ccr.cancer.gov/Laboratory-of-Cancer-Biology-and-Genetics). The overarching goal of the CBOT Section within the LCBG is to understand the complex role of the TGF-β family in regulating breast cancer progression and to use this information to develop novel therapeutic strategies. We use multiple preclinical mouse models of metastatic breast cancer coupled with a wide range of molecular biology, cell biology and imaging approaches to address these questions. We developed a novel functional imaging reporter system for identification and tracking of the cancer stem cell both in vivo and ex vivo (Tang et al. Stem Cell Reports (2015) 4:155-169). This approach allows real-time monitoring of the location and behavior of cancer stem cells in their native environment with all the contextual cues intact.Responsibilities:
The successful candidate will use this reporter to address important questions about the role of the cancer stem cell in metastatic progression and therapy-resistance, and investigate underlying molecular mechanisms.Qualifications:
Interested candidates must have a Ph.D. and/or an MD, and have less than 3 years of postdoctoral experience. A strong background in cellular/molecular biology techniques is required, and experience with 3D organoid culture is desirable. Preference will be given to candidates with extensive experience in fluorescence microscopy, image acquisition and analysis. This is a time-limited renewable appointment with stipend commensurate with experience.To Apply:
Applicants should submit a cover letter describing their research experience and interests, CV including bibliography and contact information for three references to: Dr. Lalage Wakefield (lw34gnih.gov).
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.