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Structure and Mechanisms of Cellular and Viral Noncoding RNAs and RNPsPosted by: National Institutes of Health (NIH)
Posted date: 2019-Sep-27
A postdoctoral position is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a lack of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to work on gene-regulatory riboswitches, highly structured viral RNAs, long noncoding RNAs and their RNP complexes. For additional information, please visit: https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html.
The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The lab has dedicated access to complete suites of state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc., for X-ray crystallography; Titan Krios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE and FAES.
We apply innovative technologies to study RNA and RNP structure, dynamics, and interactions, such as RNA engineering, RNA cryo-EM, XFEL, ultrafast SAXS/WAXS, single-molecule fluorescence, etc. Ongoing projects include structural and mechanistic elucidations of the T-box riboswitches (in bacteria) and Gcn2 kinase (in eukaryotes) in cellular starvation responses. A second area addresses how numerous viral and host structured noncoding RNAs differentially manipulate immune protein activities such as PKR. Relevant publications include: Hood et al., 2019 Nat. Commun; Li et al., in press; Suddala et al., in revision Zhang et al., 2014 Mol. Cell; Zhang el al., 2013 Nature, etc. Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can then take to your independent positions.Qualifications:
Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, RNA biology, or structural biology is desirable.To Apply:
Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhangnih.gov. Application Deadline Date: December 31st, 2019.
The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer. The NIH is dedicated to building a diverse community in its training and employment programs.