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Investigating the Organization and Function of Centrosomal Protein Complexes Using Single-Molecule Tracking and/or Classical Cell Biological Approaches Including Super-Resolution ImagingPosted by: National Institutes of Health (NIH)
Posted date: 2019-Oct-09
We are mainly interested in understanding the structural basis of how various centrosomal protein complexes are generated and how these complexes work together to form a macroscale assembly with distinct cellular functions. Recently, we found that Polo-like kinases (Plk4 and Plk1) form high M.W. complexes with diverse binding targets. Tight regulation of the formation of these complexes appears to be critically required for the prevention of cancer development in humans. Thus, we aim to investigate the molecular mechanisms of how these complexes are formed and how they further interact with one another to promote cellular processes central for cell cycle progression, proliferation and tumorigenesis.
Salary starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance. Fellows who have an expertise in classical cell biology and biochemistry with an interest in single-molecule tracking are encouraged to apply.
For more information, please visit: https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee.Qualifications:
Applicants should have a Ph.D. (or expected) or M.D. equivalent at the time of joining the lab.To Apply:
Please send CV and three names of references to Dr. Kyung Lee (kyungleemail.nih.gov).
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.