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Synthetic Biology and Interfacial CatalysisPosted by: Postdoc positions by NIH
Posted date: 2019-Oct-11
When enzymes are displayed at a nanoparticle interface in a controlled and homogeneous manner, in many cases they display substantially enhanced catalytic activity. We are interested in understanding the mechanisms by which enzyme activity is altered and enhanced at this nanoparticle interface and learning how to exploit this. We are particularly interested in designing and assembling totally artificial enzyme-based biosynthetic pathways on nanoparticles in vitro where the overall catalytic flux through the system can be expected to be greatly enhanced by what appears to be channeling behavior. This approach represents an important and complementary way of achieving biocatalysis for synthetic biology that is still extremely underutilized.
This position is at the interface of biology and materials and focuses on creating new biocataltyic enzyme-based nanomaterials with emergent properties.
Candidates desired experience to include a PhD in a related biological discipline such as enzymology, molecular biology, or biochemistry, with some combination of experience in cloning and recombinant DNA technology, enzymatic assays, fluorescence, bacterial-eukaryotic cell expression and analysis, biosensing, and synthetic biology. Experience with nanoparticles/nanomaterials and FRET are a plus.To Apply:
Please send a CV and cover letter indicating the position you are interested in to Igor.medintznrl.navy.mil.