We have changed our domainWe have changed servers and operate Career|edu under a different domain. Our services will remain unchanged and we will continue to post the best career openings for the academic world at our new domain.
Go back to the Job List
PhD position in the biomedical Innovative Training Network “Thrombo-Inflammation in Cardiovascular Disease” (TICARDIO)Posted by: TICARDIO
Posted date: 2019-Dec-03
PhD position in the biomedical Innovative Training Network “Thrombo-Inflammation in Cardiovascular Disease” (TICARDIO)
PhD position 6: Tissue factor pathway and extracellular vesicles in thrombo-inflammation in the Innovative Training Network (ITN) TICARDIO
We offer a PhD position for biomedical doctoral students at the Center for Thrombosis and Hemostasis (University Medical Center Mainz, Germany) and the Center for CardioVascular and Nutrition research (C2VN at Aix-Marseille Université, France). As this project is part of the MSCA ITN “Thrombo-Inflammation in Cardiovascular Disease” (TICARDIO), you will be trained in an international, interdisciplinary joint doctoral degree program striving to train the next generation of biomedical researchers. Your PhD project will be supervised by Prof. Dr. Wolfram Ruf in Mainz and by Prof. Dr. Francoise Dignat-George in Marseille. Furthermore, a research stay at BioCytex (Marseille, France, Dr. Philippe Poncelet) offers you the opportunity to get insights into research in the industry.
Conditions of Employment
This project offers good conditions of employment.
This project aims to understand how the release mechanisms generating EV from blood (monocytes) and vessel wall cells determine the protein and lipid compositions of EV. You will study how these properties of EV influence the delivery of cargo and impact interactions with blood cells and the endothelium in thrombo-inflammation. You will be trained in cell biology and omics approaches and develop imaging techniques for the visualization of EV-associated proteins. You will investigate the interactions of EV with vascular cells and analyze TF-bearing- EV initiate and disseminate intravascular coagulation processes.
The ultimate goal is to develop new diagnostic approaches for measuring functional activities of EV (e.g high sensitivity TF assays) and develop novel methods for imaging EV interactions with vessel wall cells using microfluidic devices in vitro and established thrombosis models in vivo. The long- term perspective of this project is a better definition of the roles of EV in thrombosis and determine their potential to elicit inflammatory cell signaling.