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Elucidation of Proteomic Instability in Cancer and The Role of HSF1 in OncogenesisPosted by: National Institutes of Health (NIH)
Posted date: 2019-Dec-06
Dr. Chengkai Dai’s laboratory at the Mouse Cancer Genetics Program (MCGP), National Cancer Institute, USA has an open post-doctoral position. The candidate will participate in projects that elucidate proteomic instability of cancer and tumor-associated amyloidogenesis, new phenomena in cancer biology, and investigate the multifaceted pro-oncogenic roles of heat shock factor 1 (HSF1). HSF1, the master transcriptional regulator of the heat-shock or proteotoxic stress, response, plays a critical role in preserving proteomic stability under stress conditions. Contrasting with its dispensability for primary cells, cancerous cells become dependent on HSF1, a phenomenon referred to as “non-oncogene addiction”. Recently, HSF1 has been identified by Project Achilles as a common essential gene for a broad range of human cancer cell lines (https://depmap.org/portal/achilles/).
Dr. Dai’s laboratory is conducting interdisciplinary research in the emerging field of proteomic instability of cancer. His recent research uncovers that amyloidogenesis, due to disruption of proteome homeostasis or proteostasis, is tumor-suppressive and that HSF1 plays a critical role in suppressing amyloidogenesis (Cell. 2015, 160:729-44; Nature Cell Biology. 2016, 18:527-39; Mol Cell. 2019, 76:546-561). Detailed information about Dr. Dai’s research and publications can be accessed at https://ccr.cancer.gov/Mouse-Cancer-Genetics-Program/chengkai-dai.Qualifications:
Motivated candidates with a background in biochemistry, cell or cancer biology are encouraged to apply. Experience with ChIP-seq is a big plus. Applicants should have a Ph.D. degree with a strong publication record. Good oral and written communication skills are required.To Apply:
Applications, sent by e-mail to chengkai.dainih.gov. Phone (301) 846-5227, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information of three references (inclusion of the current supervisor is preferred).
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The NIH is an equal opportunity employer.