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Modulation of Host Keratinocytes by Tick Salivary ProteinsPosted by: National Institutes of Health (NIH)
Posted date: 2020-Feb-14
The Tick-Pathogen Transmission Unit at Laboratory of Bacteriology (LB), Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) is seeking to recruit an outstanding postdoctoral fellow to study how ticks evade and exploit host keratinocytes and its relevance to tick feeding and Borrelia burgdorferi transmission. The project involves biochemical characterization of tick salivary proteins. These tick salivary proteins will be tested for anti-inflammatory activity in animal models and in cultured mouse keratinocytes. RNA silencing and utilization of knockout animals will be used in tick feeding experiments to test the hypothesis that keratinocyte modulation contributes to the tick’s ability to successfully acquire a blood meal and transmit Borrelia burgdorferi. The goal of this research is to explore the role of keratinocytes and their modulation by tick saliva in tick feeding and pathogen transmission. The ultimate goal is to identify potential new pathogen blocking strategies.
Through the Research Technologies Branch, our lab has access to state-of-the-art research technologies including flow cytometry, genomics, protein chemistry, structural biology, microscopy, among others. For additional information on the Research Technologies Branch, please visit: https://www.niaid.nih.gov/research/research-technologies-branch.
The Rocky Mountain Laboratories (RML) are located in Hamilton, Montana, a small but thriving community nestled between the Bitterroot and Sapphire Mountains. For additional information on the Rocky Mountain Laboratories, please visit: https://www.niaid.nih.gov/about/rocky-mountain-bitterroot-valley.
As a key component of the Division of Intramural Research, RML is perhaps best known for its research into vector-borne diseases, such as Rocky Mountain spotted fever, Q fever, and Lyme disease—three illnesses caused by microbes whose names pay tribute to the former RML scientists who discovered them. For additional information on the history of the Rocky Mountain Laboratories, please visit: https://www.niaid.nih.gov/about/rocky-mountain-history.
In terms of scientific opportunities, the NIH is absolutely unique in bringing scientists from virtually all areas of biomedical sciences in one Institute. A program fostering scientific exchange and collaboration between NIAID laboratories in Hamilton and Bethesda/Rockville is available and the successful applicant will have opportunities to collaborate with these labs and groups. Visit NIAID Careers for more information about working in NIAID’s dynamic atmosphere. The salary and benefits are as per NIH regulations commensurate with experience.Qualifications:
Applicants should send a short statement of research goals, curriculum vitae, bibliography, and names and contact information of three references to Dr. Lucas Tirloni (lucas.tirloninih.gov). Selected candidates will be invited for an online interview. Tentative starting date: June 2020.
Underrepresented minorities are especially encouraged to apply. NIH is dedicated to building a diverse community in its training and employment programs. HHS, NIH, and NIAID are equal opportunity employers.