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Investigating the Structure and Function of Centrosomal Self-Assemblies by X-ray Crystallography and/or NMRPosted by: National Institutes of Health (NIH)
Posted date: 2020-Feb-14
The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies. Investigating how these molecules interact with one another to form a higher-order structural entity with a new biological function is a key step to unlocking the mystery of life. We are mainly interested in understanding the molecular bases of how the physicochemical properties of pericentriolar scaffold proteins drive the formation of micron-scale self-assemblies with distinct cellular functions. Recently, we found that human polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffold proteins, which cooperatively self-assemble into a higher-order architecture around a centriole in a concentration-dependent manner. Notably, a failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly. Thus, we aim to elucidate the molecular mechanism underlying the assembly of pericentriolar architectures to ultimately understand the etiology of centrosome-associated human diseases.
For more information, please visit: https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee. Salary starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance.
Fellows, who have an expertise in X-ray crystallography and/or NMR with a keen interest in investigating the structure and function of centrosomal scaffold proteins are encouraged to apply.
Applicants should have a Ph.D. (or expected) or M.D. equivalent at the time of joining the lab.To Apply:
Please send CV and three names of references to Dr. Kyung Lee (kyungleemail.nih.gov).
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training programs.