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Glis Transcription Factors & Transcriptional Regulation, Stem Cells and DiseasePosted by: National Institutes of Health (NIH)
Posted date: 2020-Feb-14
Postdoctoral Fellowships are immediately available in the Jetten Lab at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) to study the mechanisms of GLIS transcription factors, their transcriptional regulation of target genes, their roles in the regulation of stem cell differentiation along various lineages, including neural lineages, and to understand the causal mechanism in which they are implicated in neural, renal, immune and endocrine diseases. With an interdisciplinary research environment and strong intramural support, these positions provide a unique opportunity for recent PhD awardees to carry out novel research and advance their research career. These positions are fully supported by NIH intramural funds and successful candidates will be offered competitive stipend/health insurance commensurate with experience and accomplishments.
The Jetten group studies the molecular mechanisms by which GLIS transcription factors regulate gene transcription, control biological functions and are implicated in various pathologies. The Jetten Lab uses embryonic stem cells (ESC) and its differentiated lineages, as well several transgenic mouse strains, as model systems to identify the molecular mechanisms that underlie various human diseases particularly neural, renal and metabolic disorders, as well as diabetes and inflammatory disease, in the hope that this will lead to new effective therapies.
For additional information, please visit: https://www.niehs.nih.gov/research/atniehs/labs/iidl/pi/cell-bio/index.cfm; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123274/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707155/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368876/Responsibilities:
Successful candidates will undertake several exciting new projects in the areas of transcriptional regulation, stem cell, endocrine, renal or neural biology. He/She will employ a combination of molecular biology, biochemistry and functional strategies (ChIP-Seq, single cell RNA-Seq) to elucidate the role of GLIS transcription factors in the control of several physiological functions, the mechanisms by which they regulation gene expression and are implicated in disease.Qualifications:
Candidates should have obtained a Ph.D. or M.D. degree in Biological Sciences or a related discipline within the last 5 years. and have extensive training in biochemistry and/or molecular biology (e.g., single cell RNA-Seq, ChIP-Seq; CRISPR). Experience in stem cell biology and differentiation, endocrine, neural, renal and inflammatory disorders, and respective mouse models, are also highly desirable but not essential. Excellent communications skills and a strong work ethic are essential.To Apply:
Applicants should send curriculum vitae and 3 letters of reference (via email only) to: jettennih.gov. Applications will be continuously reviewed until the position is filled.
The NIH is dedicated to building a diverse community in its training and employment programs. The NIH is an equal opportunity employer.