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Single-cell Genomics and Genetics of Embryonic Cell Fate DecisionsPosted by: National Institutes of Health (NIH)
Posted date: 2020-Feb-26
The Unit on Cell Specification and Differentiation is recruiting for a postdoctoral position in the lab of Dr. Jeffrey Farrell. The lab combines single-cell genomics, imaging, genetic, and classical embryological approaches to investigate how cell types are specified and then how cells differentiate during vertebrate embryogenesis. We focus on zebrafish embryos as a model system to study these questions, because among vertebrates, they are easy to culture, image, and manipulate both embryologically and genetically. We are located on the extremely collegial NIH campus, in Bethesda, MD, which is part of the greater Washington D.C. area.
We recently used single-cell RNAseq to profile zebrafish embryos during early development and developed a computational approach to reconstruct the gene expression trajectories that cells traverse during early cell fate decisions (Science 2018). The lab’s current research interests involve profiling the cascades of gene expression that direct specified cells to differentiate and acquire unique morphological and functional properties, and to continue to study early embryonic cell fate decisions, including how those decisions are shaped by cells’ environmental and developmental histories. Post-docs in the lab will pursue these questions using a combination of experimental and computational approaches.
Further details and a list of publications can be found at: http://www.farrell-lab.org/Qualifications:
Submit (via email) a cover letter (2-3 paragraphs describing your desired start date, research experience, and why you would like to join us), curriculum vitae, and the names and contact information of three references to:
The NIH is dedicated to building a diverse community in its training and employment programs. Women and underrepresented minorities are especially encouraged to apply.